Does ponatinib cross the blood-brain barrier?
نویسندگان
چکیده
منابع مشابه
Blood-brain Barrier Passage Does Pb Cross the Blood-brain Barrier during Conditions of Stress?
Pyridostigmine bromide is a carbamate AChE inhibitor with a positively charged “quaternary ammonium” group, which is believed to prevent its penetration through the “blood-brain barrier,” a layer of cells that controls which substances may penetrate from the general circulation into the brain. Therefore, side effects of PB are typically those of heightened peripheral cholinergic activity (nicot...
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متن کاملThe blood-brain barrier.
In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay of its cellular and acellular components a...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2016
ISSN: 0007-1048
DOI: 10.1111/bjh.14222